Publications

Beyond Structure: The Dynamic Role of the Extracellular Matrix Components in Immune Evasion.

Mohsin Maqbool; Anju Surendranath; Sadaf Khursheed Baba; Tooba Jawwad; Imadeldin Elfaki; Rashid Mir; Rakesh Kumar; Shahab Uddin; Mohammad Haris; Muzafar Ahmad Macha; Ammira Al-Shabeeb Akil; Mayank Singh; Sameer Mirza; Ajaz Ahmad Bhat

Cancer communications (London, England) · 2026 · 46: 0045

Reviews how tumor extracellular matrix remodeling shapes immune exclusion and T-cell activity. Integrates molecular mechanisms, fibroblast effects and matrix-directed treatment strategies. Discusses biomarker selection and translational challenges for combining these approaches with immunotherapy.

Combined Effects of Physiotherapy and Vitamin D Supplementation on Pain, Disability, and IL-6 Expression in Chronic Low Back Pain: A Randomized Controlled Trial.

Abdulaziz A Albalwi; Hamad S Al Amer; Rashid Mir; Shahul Hameed Pakkir Mohamed; Jamsheed Javid; Mohammad Muzaffar Mir; Waad Alamri; Yousef M Alshehre; Ahmad A Alharbi

Life (Basel, Switzerland) · 2026 · 16(8): 1288

Compares physiotherapy alone with physiotherapy plus vitamin D in 60 patients with chronic low back pain and low vitamin D. The combined group showed greater six-week improvements in pain and disability and lower IL-6. Findings apply to this selected population and short follow-up period.

Development and evaluation of an indigenous Salmonella gallinarum ghost vaccine for the control of fowl typhoid in poultry.

Asad Ullah Ghalib; Sajjad Hussain; Waseem Shahzad; Rashid Mir; Bushra Muneer

Iranian journal of microbiology · 2026 · 18(4): 574-583

Develops a chemically produced Salmonella gallinarum ghost vaccine and tests vaccination routes in poultry. Vaccinated birds showed increased antibody responses, with the intramuscular route producing the strongest sustained response. The study evaluates a veterinary disease-control approach rather than a human vaccine.

Diffuse Large B-Cell Lymphoma: From Molecular Stratification to Precision Immunotherapy.

Akbar Pasha; Aayushi Velingkar; Ramita Sharma; Priyanka Tiwari; Manasi Mundada; Rohan Tewani; Dylan T Jochum; Rashid Mir; Faiq Ahmed; Sugunakar Vuree; Gopal Gopisetty; Senthil J Rajappa; Aisha Ahmad Al-Khinji; Mallick Saumyaranjan; Chengfeng Bi; Waseem G Lone

Cells · 2026 · 15(13): 1188

Reviews molecular classification and treatment selection in diffuse large B-cell lymphoma. Integrates genomic profiling, tumor microenvironment features and evidence for targeted and immune therapies. Discusses biomarkers and sequencing of treatments in relapsed or refractory disease.

Evaluation of genetic studies on camels in Saudi Arabia: traits, tools, and applications.

Abdulrahman AlAsmari; Rashid Mir

Tropical animal health and production · 2026 · 58(2): 110

Reviews Saudi camel genetics, genomic tools and applications to breeding and conservation. Discusses genetic diversity, adaptive traits and nanobody-related biomedical potential. Identifies fragmented data and limited integration into national programs as research gaps.

Exploring the Association of Genetic Determinants of SIRT1, MTHFR, and MIR146A Gene Polymorphism with the Ischemic Stroke Predisposition: A Case Control Study.

Abdullah Hamadi; Rashid Mir; Osama M Al-Amer; Mohammed Alasseiri; Mamdoh S Moawadh; Jameel Barnawi; Mohammad A Alanazi; Atif Abdulwahab A Oyouni; Abeer Al-Tuwaijri; Fawzyah Obeedallah Albaldi; Hassan A Madkhali

Cellular and molecular neurobiology · 2026 · 46(1): 85

Examines SIRT1, MTHFR and MIR146A variants in a case-control study of ischemic stroke. Reports genotype and allele associations with susceptibility in the studied population. Independent larger studies are needed before these findings inform genetic screening.

Host systemic metabolism and cancer metabolic vulnerabilities: mechanisms and therapeutic opportunities.

Rashid Mir; Jameel Barnawi; Naseh A Algehainy; Mohammed M Jalal; Malik A Altayar; Reema M Almotairi; Faris J Tayeb; Mamdoh S Moawadh; Ruqaiah I Bedaiwi; Kholoud S Almasoudi; Ibrahim Altedlawi Albalawi; Abdulrahman Alasmari; Mohammad Muzaffar Mir

Frontiers in oncology · 2026 · 16: 1897564

Reviews how systemic metabolism, oncogenic signaling and mitochondrial adaptation influence cancer. Examines metabolic flexibility, epigenetic regulation and interactions with immune cells. Discusses established targets and investigational combinations intended to limit adaptive resistance.

Identification of novel and known variants in GAA, MYH6, NEXN, ATA3A, RHBDF1, and ACTA1 genes in coronary artery disease patients by Whole-exome sequencing.

Rashid Mir; Mohammad Fahad Ullah; Jamsheed Javid; Imadeldin Elfaki; Faisal H Altemani; Jameel Barnawi; Naseh A Algehainy; Mohammed M Jalal; Malik A Altayar; Aadil Yousif; Eram Hussain; Faris J Tayeb; Faisel M AbuDuhier; Salem Owaid Albalawi; Syed Khalid Mustafa

Frontiers in cardiovascular medicine · 2026 · 13: 1853197

Uses whole-exome sequencing in 28 coronary artery disease patients to characterize cardiac gene variants. Reports known and novel candidate variants affecting structural and functional cardiac pathways. The small exploratory cohort supports further functional and population-level validation.

Identification of novel genomic variants in diabetic nephropathy patients using whole-exome sequencing: a pilot investigation.

Rashid Mir; Imadeldin Elfaki; Rehab F Almassabi; Sanaa Almowallad; Mohamed E Elnageeb; Hyder Osman Mirghani; Wed Albalawi; Aziz Dhaher Albalawi; Faisal H Altemani; Jameel Barnawi; Faris J Tayeb; Mamdoh Moawadh; Ruqaiah I Bedaiwi; Mohammad A Alanazi

Frontiers in endocrinology · 2026 · 17: 1798640

Uses whole-exome sequencing to investigate candidate variants in diabetic nephropathy. Identifies shared and disease-related loci and potentially novel missense changes. Functional studies and larger cohorts are needed to establish their clinical relevance.

Integrated transcriptomic and functional characterization of Claudin-1 reveals its oncogenic and immunomodulatory roles in pancreatic ductal adenocarcinoma.

Anju Surendranath; Yogain Taank; Saira Hamid; Tharini Karthikeyan; Ikhlak Ahmed; Imadeldin Elfaki; Rashid Mir; Rakesh Kumar; Sameer Mirza; Mayank Singh; Shahab Uddin; Ammira S Al-Shabeeb Akil; Muzafar A Macha; Punita Dhawan; Ajaz A Bhat

Tissue barriers · 2026 · 14(3): 2648150

Combines transcriptomic analyses with functional experiments on Claudin-1 in pancreatic ductal adenocarcinoma. Elevated expression was associated with aggressive disease and reduced immune infiltration; knockout inhibited malignant cellular behaviors. The findings support further evaluation of Claudin-1 as a candidate biomarker and target.

MicroRNAs as Biomarkers for the Diagnosis and Prognosis of Different Diseases and Cancer.

Rashid Mir; Ajaz Ahmad Waza; Mohammad Muzaffar Mir

Experientia supplementum (2012) · 2026 · 115: 199-213

Reviews microRNAs as possible diagnostic and prognostic markers across cancer and other diseases. Discusses gene regulation and the potential of microRNAs detectable in body fluids. Frames their use as a developing field requiring further validation.

Natural Products in Prostate Cancer: Crosstalk Among the Gut Microbiome, Androgen Receptor Signaling, and Epigenetic Regulation.

Mohammad Muzaffar Mir; Javed Iqbal Wani; Rashid Mir; Muffarah Hamid Alharthi; Abdullah Ayed; Partha Nandi; Ayyub Ali Patel; Ayaz Khurram Mallick; Mohannad Mohammad S Alamri; Mohammed O'haj; Tarig Babikir Algak Khalid; Adnan Jehangir; Hany M A Sonpol; Ahmed Mussad Senbel

International journal of molecular sciences · 2026 · 27(13): 5956

Reviews natural products in relation to prostate cancer signaling, microbiome activity and epigenetic regulation. Discusses selected phytochemicals and their effects on interconnected biological pathways. Highlights bioavailability, variable clinical evidence and other barriers to translation.

Phenylketonuria in Saudi Arabia: An Overview of Diagnosis, Genetics, and Therapeutic Strategies.

Faris J Tayeb; Rashid Mir; Sael Alatawi

Biology · 2026 · 15(14): 1122

Reviews phenylketonuria diagnosis, PAH genetics and treatment in the Saudi context. Covers newborn screening, dietary care and established and emerging therapies. Distinguishes regional evidence from extrapolation and identifies surveillance and registry gaps.

Understanding the mechanisms underlying obesity induced tumorigenesis: therapeutic perspectives to manage dysregulated lipid metabolism.

Uzma Faridi; Rashid Mir; Naseh A Algehainy; Zeyad M Alharbi; Faris J Tayeb; Jameel Barnawi; Mohammed M Jalal; Malik A Altayar; Mamdoh Moawadh; Syed Khalid Mustafa; Mohammad Muzaffar Mir; Jaber Alfaifi; Ibrahim Abdullah Almazni

Discover oncology · 2026 · 17(1): 1149

Reviews mechanisms connecting obesity with cancer, including inflammation, adipokines and altered lipid metabolism. Examines effects on the tumor microenvironment and therapeutic response. Identifies metabolic vulnerabilities as research directions rather than established universal treatment targets.

White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure.

Pradeep Kumar Dabla; Dharmsheel Shrivastav; Vimal Mehta; Swati Singh; Rashid Mir

World journal of methodology · 2026 · 16(1): 108178

Examines blood-cell counts and neutrophil-to-HDL ratio in 200 patients with angiographically confirmed coronary disease. Higher inflammatory measures were associated with lower left ventricular ejection fraction. Discrimination was modest, supporting further evaluation rather than standalone clinical prediction.

Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.

Mohammad Fahad Ullah; Rashid Mir; Jamsheed Javid; Imadeldin Elfaki; Faisal H Altemani; Jameel Barnawi; Naseh A Algehainy; Mohammed M Jalal; Malik A Altayar; Salem Owaid Albalawi; Syed Khalid Mustafa; Aadil Yousif; Eram Husain; Faris J Tayeb; Faisel M AbuDuhier

Biomolecules & biomedicine · 2026 · 26(8): 1344-1356

Uses whole-exome sequencing to characterize variants in obstructive coronary artery disease. Identifies candidate changes in genes linked to cardiac conduction, structure and lipid metabolism. Variant annotations generate hypotheses and do not establish causation in this exploratory cohort.

A rare likely pathogenic HLA-DRB1 variant with compromised immunity in severe COVID-19 patient and in-hospital mortality.

Rashid Mir; Badr A Alsayed; Mohammad Fahad Ullah

Personalized medicine · 2025 · 22(5): 275-284

Reports whole-exome analysis of a young adult with severe COVID-19, cardiometabolic comorbidity and in-hospital death. Identifies candidate immune-related variants, including a likely pathogenic HLA-DRB1 change. A single case cannot establish the variant's causal effect on outcome.

Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population.

Abdullah Hamadi; Rashid Mir; Osama M Al-Amer; Mohammed Alasseiri; Waseem AlZamzami; Sael Alatawi; Mohammad A Alanazi; Mamdoh S Moawadh; Atif Abdulwahab A Oyouni; Abeer Al Tuwaijri; Saleh Althenayyan; Hassan A Madkhali; Raed Alserihi

Frontiers in human neuroscience · 2025 · 19: 1645598

Uses clinical exome sequencing and genotyping to investigate ischemic stroke in the Tabuk population. Reports novel GSTT4 variants and changes in lipid-related and vascular genes. These population-specific candidates require functional and larger-scale validation.

Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients.

Abdullah Hamadi; Rashid Mir; Osama M Al-Amer; Mohammed Alasseiri; Imadeldin Elfaki; Mohammad A Alanazi; Mamdoh S Moawadh; Jameel Barnawi; Atif Abdulwahab A Oyouni; Reef Idris Hamdi; Khalid I Alharbi

Cellular and molecular neurobiology · 2025 · 45(1): 106

Genotypes ANRIL, CYP2C19*17 and TCF7L2 variants in 100 stroke cases and 100 controls from Tabuk. Reports associations between selected genotypes or alleles and stroke. These are candidate susceptibility loci rather than validated screening tests.

Elucidation of Mechanisms by Which Microplastics (PET) Facilitates the Rapid Growth of Benthic Cyanobacteria and Toxin Production in Aquatic Ecosystems.

Rashid Mir; Shrooq Albarqi; Wed Albalawi; Ghaida Alanazi; Shouq S Alsubaie; Razan I Alghaban; Hanadi Saud Alanazi; Nora Taleb Alsharif; Manal M Aljammaz; Nouf Faisal Alghabban; Wafaa Seluman Alhwiti; Alaa Albogmi; Faras Falah Alblwi

Metabolites · 2025 · 15(6): 383

Reviews how PET microplastics and leachates interact with benthic cyanobacteria. Discusses potential effects on metabolism, stress responses, growth and toxin production. Synthesizes ecological mechanisms and research needs for polluted aquatic environments.

Emerging biomarkers in type 2 diabetes mellitus.

Mohammad Muzaffar Mir; Mushabab Alghamdi; Waad Fuad BinAfif; Muffarah Hamid Alharthi; Abdullah M Alshahrani; Mohannad Mohammad S Alamri; Jaber Alfaifi; Ahmed Yahia Al Ameer; Rashid Mir

Advances in clinical chemistry · 2025 · 126: 155-198

Reviews established and emerging biomarkers for type 2 diabetes. Examines the need for earlier and more precise disease detection. Emphasizes limitations of individual markers and the potential value of combined panels.

Evaluating the Impact of rs4025935, rs71748309, rs699947, and rs4646994 Genetic Determinants on Polycystic Ovary Syndrome Predisposition-A Case-Control Study.

Reema Almotairi; Rashid Mir; Kholoud S Almasoudi; Eram Husain; Nabil Mtiraoui

Life (Basel, Switzerland) · 2025 · 15(4): 558

Investigates glutathione-transferase and VEGF variants in a case-control study of polycystic ovary syndrome. Reports associations between selected null genotypes, alleles and syndrome susceptibility. Larger studies are needed to confirm these population-specific findings.

Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression.

Abdullah Hamadi; Rashid Mir; Osama M Al-Amer; Mohammed Alasseiri; Gasim Dobie; Imadeldin Elfaki; Waseem AlZamzami; Sael Alatawi; Atif Abdulwahab A Oyouni; Mohammad A Alanazi; Saravanan Muthupandian

PloS one · 2025 · 20(12): e0332252

Examines ANRIL, PAI-1 and HNF1alpha variants in Saudi stroke cases and healthy controls, with sequencing in a subset. Reports associations between selected polymorphisms and stroke susceptibility. These findings identify candidates for replication and functional investigation.

Extracellular derived-exosomal micrornas in pancreatic cancer: investigating their diagnostic importance and potential targets for the prevention and treatment in pancreatic cancer.

Rashid Mir; Ulfat Jan; Jameel Barnawi; Naseh A Algehainy; Mohammed M Jalal; Malik A Altayar; Reema M Almotairi; Tarig Ms Alnour; Syed Khalid Mustafa; Abdulaziz S Al-Otaibi; Adel D Althaqafy; Elham M Alhathli; Salma Alrdahe; Mohammad Muzaffar Mir; Nada Zaki Sageer; Abdullatif Taha Babakr; Afaq Ahmad Khan

Frontiers in oncology · 2025 · 15: 1669213

Reviews exosomal microRNAs in pancreatic cancer detection, prognosis and treatment research. Discusses signaling networks involving prominent microRNAs and comparisons with other cancers. Highlights methodological and translational obstacles to clinical application.

Genetic Variations in BCL3, MDM4, KLF14, and miR-146a and Their Associations with the Predisposition and Progression of Myeloproliferative Disorder and Chronic Myeloid Leukemia Patients.

Osama M Al-Amer; Mohammed I Alasseiri; Faris J Tayeb; Mansour A Alanazi; Abdullah Hamadi; Mohammed M Jalal; Malik A Altayar; Reema M Almotairi; Hanan A Niaz; Mamdoh Moawadh; Sael Alatawi; Waseem AlZamzami; Atif Abdulwahab A Oyouni; Mohammed Alassiri; Fahad Alharthi; Hussam A Althagafi; Mohammad A Alanazi; Rashid Mir

Molecular syndromology · 2025 · 16(6): 517-529

Genotypes BCL3, MDM4, KLF14 and miR-146a in patients with myeloproliferative disorders or chronic myeloid leukemia and controls. Reports different genotype and allele distributions between groups. Further validation is needed to establish predictive or prognostic utility.

Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update.

Imadeldin Elfaki; Rashid Mir; Mohamed E Elnageeb; Abdullah Hamadi; Zeyad M Alharbi; Ruqaiah I Bedaiwi; Jamsheed Javid; Tariq Alrasheed; Dalal Alatawi; Basmah M Alrohaf; Mohammed K Abunab; Turki Ahmed Muqri

Medicina (Kaunas, Lithuania) · 2025 · 61(1): 83

Reviews genetic loci associated with insulin resistance and metabolic syndrome. Connects susceptibility research with diabetes, cardiovascular disease and related conditions. Discusses risk stratification and prevention while identifying areas requiring further study.

Identification of Novel Genomic Variants in COVID-19 Patients Using Whole-Exome Sequencing: Exploring the Plausible Targets of Functional Genomics.

Rashid Mir; Faisal H Altemani; Naseh A Algehainy; Mohammad A Alanazi; Imadeldin Elfaki; Badr A Alsayed; Mohammad Muzaffar Mir; Syed Khalid Mustafa; Mamdoh S Moawadh; Faris J Tayeb; Jaber Alfaifi; Sael M Alatawi; Mohammed Saad Alhiwety; Mohammad Fahad Ullah

Biochemical genetics · 2025 · 63(6): 4980-5000

Uses whole-exome sequencing to explore genetic differences in COVID-19 patients. Reports candidate variants and network relationships involving immune and disease-related pathways. The findings are exploratory; the associated correction should be consulted alongside the article.

Related correction

Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach.

Rashid Mir; Jamsheed Javid; Mohammad Fahad Ullah; Salma Alrdahe; Ibrahim Abdullah Altedlawi; Syed Khalid Mustafa; Mohammed M Jalal; Malik A Altayar; Aziz Dhaher Albalawi; Muhammed Kamal Abunab; Hanadi Saud Alanazi; Jameel Barnawi; Naseh A Algehainy; Faisal H Altemani; Faris J Tayeb

Medical oncology (Northwood, London, England) · 2025 · 42(9): 373

Reviews metabolic exchanges and competition among cells in the tumor microenvironment. Discusses how integrated genomic, transcriptomic, proteomic and metabolomic analyses reveal metabolic heterogeneity. Explores potential therapeutic vulnerabilities arising from these interactions.

Metagenomic Characterization of Microbiome Taxa Associated with Coral Reef Communities in North Area of Tabuk Region, Saudia Arabia.

Madeha O I Ghobashy; Amenah S Al-Otaibi; Basmah M Alharbi; Dikhnah Alshehri; Hanaa Ghabban; Doha A Albalawi; Asma Massad Alenzi; Marfat Alatawy; Faud A Alatawi; Abdelazeem M Algammal; Rashid Mir; Yussri M Mahrous

Life (Basel, Switzerland) · 2025 · 15(3): 423

Characterizes microbial communities near coral reefs in northern Tabuk using metagenomic methods. Reports differences in diversity and composition by location and proximity to coral. The findings describe ecological associations rather than demonstrating causal protection of corals.

Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.

Pradeep Kumar Dabla; Rashid Mir; Mohammad Fahad Ullah; Vimal Mehta; Jamsheed Javid; Imadeldin Elfaki; Eram Hussain; Jameel Barnawi; Mohammed M Jalal; Malik A Altayar; Ruqaiah I Bedaiwi; Syed Khalid Mustafa

Discovery medicine · 2025 · 37(197): 994-1010

Genotypes GSTP1, H19, TCF7L2 and HNF1A in coronary disease patients with and without diabetes and controls. Reports gene-specific differences in susceptibility associations between the patient groups. The findings identify population-level candidate risk markers for further validation.

Risk Assessment Analysis of Type II Diabetes Mellitus and Dyslipidemia with Coronary Artery Stenosis Scoring: Intervention Strategies.

Pradeep Kumar Dabla; Dharmsheel Shrivastav; Vimal Mehta; Swati Singh; Rashid Mir; Shyamalendu Kandar

EJIFCC · 2025 · 36(3): 298-304

Compares coronary disease patients with and without diabetes against healthy controls. Assesses lipid and glycemic measures alongside angiographic Gensini scores. Reports greater stenosis burden in diabetic coronary disease and associations warranting further study.

Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.

Alanoud Abdulla; Hana Q Sadida; Jayakumar Jerobin; Imadeldin Elfaki; Rashid Mir; Sameer Mirza; Mayank Singh; Muzafar A Macha; Shahab Uddin; Khalid Fakhro; Ajaz A Bhat; Ammira S Al-Shabeeb Akil

Journal of the National Cancer Center · 2025 · 5(1): 8-27

Reviews molecular links between obesity and cancer through a narrative literature synthesis. Examines metabolic disruption, inflammation and changes in the tumor microenvironment. Discusses potential targets and future strategies for testing these connections.

Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.

Mohammad Muzaffar Mir; Mohammed Jeelani; Muffarah Hamid Alharthi; Syeda Fatima Rizvi; Shahzada Khalid Sohail; Javed Iqbal Wani; Zia Ul Sabah; Waad Fuad BinAfif; Partha Nandi; Abdullah M Alshahrani; Jaber Alfaifi; Adnan Jehangir; Rashid Mir

International journal of molecular sciences · 2025 · 26(6): 2770

Reviews the cellular and molecular mechanisms of insulin resistance. Discusses genetic, metabolic and environmental influences on insulin signaling. Covers therapeutic approaches and gaps in biomarkers and prevention research.

Whole Exome Sequencing in 26 Saudi Patients Expands the Mutational and Clinical Spectrum of Diabetic Nephropathy.

Imadeldin Elfaki; Rashid Mir; Sanaa Almowallad; Rehab F Almassabi; Wed Albalawi; Aziz Dhaher Albalawi; Ajaz A Bhat; Jameel Barnawi; Faris J Tayeb; Mohammed M Jalal; Malik A Altayar; Faisal H Altemani

Medicina (Kaunas, Lithuania) · 2025 · 61(6): 1017

Uses whole-exome sequencing in 26 Saudi patients with diabetic nephropathy. Reports candidate variants affecting insulin-related, inflammatory and mitochondrial processes. Larger cohorts and protein-function studies are needed to confirm their relevance.

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants.

Hanan E Alatwi; Amnah A Alharbi; Rashid Mir; Othman R Alzahrani; Abdulrahman H Alessa; Yousef M Hawsawi; Mohammed Ali Arishi; Aziz Dhaher Albalawi

Frontiers in oncology · 2025 · 15: 1679528

Sequences tumor exomes from 24 Saudi colorectal cancer patients and compares variant patterns with TCGA. Reports novel and recurrent variants affecting several cancer-related pathways. The exploratory findings highlight the value of representing diverse populations in cancer genomics.

Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes.

Rashid Mir; Mohammad Fahad Ullah; Imadeldin Elfaki; Mohammad A Alanazi; Naseh A Algehainy; Faisal H Altemani; Mamdoh S Moawadh; Faris J Tayeb; Badr A Alsayed; Mohammad Muzaffar Mir; Jaber Alfaifi; Syed Khalid Mustafa; Jameel Barnawi; Salma Saleh Alrdahe

Viruses · 2025 · 17(9): 1198

Uses whole-exome sequencing in 16 Saudi COVID-19 patients with extreme clinical phenotypes. Identifies rare and novel candidate variants in immune-related and DNA-repair pathways. The pilot study generates hypotheses for larger investigations of disease susceptibility.

Association of iron deficiency anaemia with the hospitalization and mortality rate of patients with COVID‑19.

Mohammed M Jalal; Maaidah M Algamdi; Almohanad A Alkayyal; Malik A Altayar; Amr S Mouminah; Ahlam Jumaa Alamrani; Nouf Abdulaziz Althaqafi; Reem Ali Alamrani; Wjdan Salem Alomrani; Yasmin Attallah Alemrani; Marwan Alhelali; Imadeldin Elfaki; Rashid Mir

Medicine international · 2024 · 4(6): 69

Examines iron deficiency anemia in relation to outcomes among patients with COVID-19. Reports associations with prolonged hospitalization and complications. Larger studies are needed to confirm the findings and establish their predictive relevance.

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance.

Gh Rasool Bhat; Itty Sethi; Hana Q Sadida; Bilal Rah; Rashid Mir; Naseh Algehainy; Ibrahim Altedlawi Albalawi; Tariq Masoodi; Gowtham Kumar Subbaraj; Farrukh Jamal; Mayank Singh; Rakesh Kumar; Muzafar A Macha; Shahab Uddin; Ammira S Al-Shabeeb Akil; Mohammad Haris; Ajaz A Bhat

Cancer metastasis reviews · 2024 · 43(1): 197-228

Reviews cancer-cell plasticity and its contribution to tumor heterogeneity and drug resistance. Integrates cellular, molecular and genetic mechanisms of changing cell states. Discusses implications for therapeutic targeting and precision oncology research.

Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.

Jamsheed Javid; Rashid Mir; Imadeldin Elfaki; Reema Almotairi; Jameel Barnawi; Naseh A Algehainy; Mohammed M Jalal; Malik A Altayar; Mohammad A Alanazi; Salem Owaid Albalawi; Tanzeela Bhat; Eram Hussain; Faisel M AbuDuhier

Discovery medicine · 2024 · 36(190): 2287-2299

Examines vitamin D and CYP2R1, TCF7L2 and CCR5 variants in coronary artery disease. Reports associations involving selected genetic variants and vitamin D deficiency. Larger case-control and functional studies are needed before clinical use.

Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment.

Rashid Mir; Shrooq A Albarqi; Wed Albalawi; Hanan E Alatwi; Marfat Alatawy; Ruqaiah I Bedaiwi; Reema Almotairi; Eram Husain; Mohammad Zubair; Ghaida Alanazi; Shouq S Alsubaie; Razan I Alghabban; Khalid A Alfifi; Shabnam Bashir

Metabolites · 2024 · 14(12): 683

Reviews relationships between gut microbiota and breast cancer development. Discusses possible mechanisms, risk associations and microbiome-directed treatment research. Individualized clinical applications remain an area for further investigation.

Exploring the Association of Biochemical Characterization and Genetic Determinants of TNF-α, CXCR2, and CCR5 Delta 32 Mutation with Predisposition to Polycystic Ovary Syndrome.

Kholoud S Almasoudi; Eram Hussain; Reema Almotairi; Tanzeela Bhat; Nabil Mtiraoui; Intissar Ezzidi; Rashid Mir

Life (Basel, Switzerland) · 2024 · 14(8): 949

Examines biochemical features and TNF-alpha, CXCR2 and CCR5 variants in polycystic ovary syndrome. Reports associations with susceptibility in the Tabuk population. Longitudinal and larger multi-population studies are needed before risk classification.

Extracellular vesicles as tools and targets in therapy for diseases.

Mudasir A Kumar; Sadaf K Baba; Hana Q Sadida; Sara Al Marzooqi; Jayakumar Jerobin; Faisal H Altemani; Naseh Algehainy; Mohammad A Alanazi; Abdul-Badi Abou-Samra; Rakesh Kumar; Ammira S Al-Shabeeb Akil; Muzafar A Macha; Rashid Mir; Ajaz A Bhat

Signal transduction and targeted therapy · 2024 · 9(1): 27

Reviews extracellular vesicles as diagnostic tools, drug carriers and therapeutic targets. Covers cancer and several non-cancer disease settings. Discusses opportunities based on vesicle contents and the challenges of translating them into clinical practice.

Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma.

Sana Khurshid; Shahabuddin Usmani; Raiyan Ali; Saira Hamid; Tariq Masoodi; Hana Q Sadida; Ikhlak Ahmed; Mohd Shahnawaz Khan; Inara Abeer; Ibrahim Altedlawi Albalawi; Ruqaiah I Bedaiwi; Rashid Mir; Ammira S Al-Shabeeb Akil; Ajaz A Bhat; Muzafar A Macha

Frontiers in molecular biosciences · 2024 · 11: 1425422

Integrates differential-expression and network analyses in esophageal squamous cell carcinoma. Identifies candidate hub genes and assesses prognostic and therapeutic relevance, including MMP9. Computational associations require independent and functional validation.

Integrative Metagenomic Analyses Reveal Gut Microbiota-Derived Multiple Hits Connected to Development of Diabetes Mellitus.

Sehad N Alarifi; Essam Jamil Alyamani; Mohammed Alarawi; Azzam A Alquait; Mohammed A Alolayan; Ahmad M Aldossary; Randa A Abd El-Rahman; Rashid Mir

Metabolites · 2024 · 14(12): 720

Compares gut microbiota in Saudi individuals with type 2 diabetes and healthy controls. Reports differences in bacterial composition and abundance between groups. Larger studies are needed to distinguish disease associations from confounding and evaluate clinical relevance.

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve, Saudi Arabia.

Yahya S Al-Awthan; Rashid Mir; Fuad A Alatawi; Abdulaziz S Alatawi; Fahad M Almutairi; Tamer Khafaga; Wael M Shohdi; Amal M Fakhry; Basmah M Alharbi

Life (Basel, Switzerland) · 2024 · 14(12): 1692

Profiles microbial diversity in sandy soils near natural and artificial water sources in a Saudi reserve. Uses sequencing and functional categorization to describe dominant taxa and metabolic capabilities. Provides an ecological baseline for understanding these environments.

Metagenomic Analysis of Sediment Bacterial Diversity and Composition in Natural Lakes and Artificial Waterpoints of Tabuk Region in King Salman Bin Abdulaziz Royal Natural Reserve, Saudi Arabia.

Yahya S Al-Awthan; Rashid Mir; Basmah M Alharbi; Abdulaziz S Alatawi; Fahad M Almutairi; Tamer Khafaga; Wael M Shohdi; Amal M Fakhry; Mashari M Alatawi

Life (Basel, Switzerland) · 2024 · 14(11): 1411

Uses metagenomic analysis to characterize sediment bacteria at natural and artificial waterpoints in a Saudi reserve. Reports substantial taxonomic diversity and differences among sampling environments. The study supplies baseline ecological information relevant to monitoring and conservation.

Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients.

Badr A Alsayed; Rashid Mir; Mohammad M Mir; Tarig M S Alnour; Shereen Fawzy; Mesaik M Ahmed; Dnyanesh Amle

Current genomics · 2024 · 25(1): 12-25

Examines TNF-alpha, IL-8, IL-10 and CXCR2 polymorphisms in COVID-19 patients. Reports associations with susceptibility and mortality in the studied cohort. Larger independent samples are needed to confirm these candidate genetic links.

Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus.

Mohamed E Elangeeb; Imadeldin Elfaki; Ali M S Eleragi; Elsadig Mohamed Ahmed; Rashid Mir; Salem M Alzahrani; Ruqaiah I Bedaiwi; Zeyad M Alharbi; Mohammad Muzaffar Mir; Mohammad Rehan Ajmal; Faris Jamal Tayeb; Jameel Barnawi

Molecules (Basel, Switzerland) · 2024 · 29(8): 1904

Uses molecular dynamics to assess structural effects of selected Kir6.2 variants. Identifies changes that could alter channel structure or function in diabetes. Protein-function experiments and population studies are needed to test these computational predictions.

Potential Association of The Pathogenic Kruppel-like Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM.

Imadeldin Elfaki; Rashid Mir; Faris Tayeb; Adel I Alalawy; Jameel Barnawi; Pradeep Kumar Dabla; Mamdoh Shafig Moawadh

Endocrine, metabolic & immune disorders drug targets · 2024 · 24(9): 1090-1100

Examines KLF14 and ADIPOQ variants in relation to type 2 diabetes susceptibility. Reports genotype and allele associations in the studied population. Larger cohorts and functional analyses are needed before clinical genetic testing.

The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity.

Mohammad Muzaffar Mir; Jaber Alfaifi; Shahzada Khalid Sohail; Syeda Fatima Rizvi; Md Tanwir Akhtar; Mushabab Ayed Abdullah Alghamdi; Rashid Mir; Javed Iqbal Wani; Zia Ul Sabah; Fahad A Alhumaydhi; Fahad Alremthi; AbdulElah Al Jarallah AlQahtani; Muffarah Hamid Alharthi; Masoud Ishag Elkhalifa Adam; Imadeldin Elfaki; Hany M A Sonpol

Journal of personalized medicine · 2024 · 14(7): 743

Measures CCL1, CCL2, CCL4 and CCL5 in people with type 2 diabetes across obesity categories. Reports differences in inflammatory chemokine profiles, including increased CCL5. The findings motivate further investigation of adiposity, inflammation and insulin resistance.

Unlocking the Secrets of Extracellular Vesicles: Orchestrating Tumor Microenvironment Dynamics in Metastasis, Drug Resistance, and Immune Evasion.

Rashid Mir; Sadaf Khursheed Baba; Imadeldin Elfaki; Naseh Algehainy; Mohammad A Alanazi; Faisal H Altemani; Faris Jamal Tayeb; Jameel Barnawi; Eram Husain; Ruqaiah I Bedaiwi; Ibrahim Altedlawi Albalawi; Muhanad Alhujaily; Mohammad Muzaffar Mir; Reema Almotairi; Hanan E Alatwi; Aziz Dhaher Albalawi

Journal of Cancer · 2024 · 15(19): 6383-6415

Reviews extracellular vesicles as mediators of tumor microenvironment interactions. Discusses their roles in metastasis, drug resistance and immune evasion. Considers diagnostic and therapeutic possibilities arising from these signaling processes.

Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, HFE p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality.

Rashid Mir; Imadeldin Elfaki; Mohammad A Alanazi; Naseh A Algehainy; Faisal H Altemani; Badr A Alsayed; Elsiddig Idriss Mohamed; Syed Khalid Mustafa; Mamdoh S Moawadh; Faris J Tayeb; Jaber Alfaifi; Sael M Alatawi; Mohammad Muzaffar Mir; Mohammad Fahad Ullah

Discovery medicine · 2024 · 36(186): 1513-1526

Uses whole-exome sequencing to investigate HFE H63D and other candidate variants in COVID-19 patients. Examines variant occurrence in relation to clinical disease and mortality. The reported associations require independent confirmation before use for individual risk prediction.

Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma.

Osama M Al-Amer; Rashid Mir; Abdullah Hamadi; Mohammed I Alasseiri; Malik A Altayar; Waseem AlZamzami; Mamdoh Moawadh; Sael Alatawi; Hanan A Niaz; Atif Abdulwahab A Oyouni; Othman R Alzahrani; Hanan E Alatwi; Aishah E Albalawi; Khalaf F Alsharif; Ashraf Albrakati; Yousef M Hawsawi

Cancers · 2023 · 15(4): 1012

Compares selected antiapoptotic gene genotypes and alleles in lymphoma patients and healthy individuals. Reports higher prevalence of several variants among patients. Independent studies are needed before these variants inform risk classification.

Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population.

Mohammed M Jalal; Rashid Mir; Abdullah Hamadi; Malik A Altayar; Imadeldin Elfaki; Jameel Barnawi; Almohanad A Alkayyal; Mouminah Amr; Jabali Hadeel; Mamdoh S Moawadh; Basim S O Alsaedi; Marwan H Alhelali; Aadil Yousif

Life (Basel, Switzerland) · 2023 · 13(5): 1200

Examines VWF, glutathione-transferase and TNF-alpha variants in Saudi ischemic stroke. Reports candidate associations with susceptibility and progression. Larger studies and functional analyses are needed to establish biological and clinical significance.

Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients.

Dharmsheel Shrivastav; Desh Deepak Singh; Rashid Mir; Pratishtha Mehra; Vimal Mehta; Pradeep Kumar Dabla

World journal of diabetes · 2023 · 14(12): 1754-1765

Compares carboxymethyl-lysine and inflammatory measures in coronary disease with and without diabetes. Reports associations between higher marker levels and diabetic coronary disease. The markers remain candidates for further validation rather than established diagnostic replacements.

Comprehensive Molecular Evaluation of HNF-1 Alpha, miR-27a, and miR-146 Gene Variants and Their Link with Predisposition and Progression in Type 2 Diabetes Patients.

Rashid Mir; Imadeldin Elfaki; M E Elangeeb; Mamdoh S Moawadh; Faris Jamal Tayeb; Jameel Barnawi; Ibrahim Altedlawi Albalawi; Amnah A Alharbi; Marwan H Alhelali; Basim S O Alsaedi

Journal of personalized medicine · 2023 · 13(8): 1270

Examines HNF1alpha, miR-27a and miR-146 variants in Saudi patients with type 2 diabetes. Reports associations between selected variants and susceptibility. Protein-function investigations and independent larger cohorts are needed for confirmation.

Differential Expression of Serum Proinflammatory Cytokine TNF-α and Genetic Determinants of TNF-α, CYP2C19*17, miR-423 Genes and Their Effect on Coronary Artery Disease Predisposition and Progression.

Rehab F Almassabi; Rashid Mir; Jamsheed Javid; Faisel M AbuDuhier; Reema Almotairi; Marwan H Alhelali; Naseh Algehainy; Basim S O Alsaedi; Salem Owaid Albalawi; Imadeldin Elfaki

Life (Basel, Switzerland) · 2023 · 13(11): 2142

Examines serum TNF-alpha and TNF-alpha, CYP2C19*17 and miR-423 variants in coronary disease. Reports candidate genetic and inflammatory associations with susceptibility. These findings require replication before use in risk prediction.

In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes.

M E Elangeeb; Imadeldin Elfaki; M A Elkhalifa; Khalid M Adam; A O Alameen; Ahmed Kamaleldin Elfadl; Ibrahim Altedlawi Albalawi; Kholoud S Almasoudi; Reema Almotairi; Basim S O Alsaedi; Marwan H Alhelali; Mohammad Muzaffar Mir; Dnyanesh Amle; Rashid Mir

Current issues in molecular biology · 2023 · 45(9): 7449-7475

Uses computational methods to investigate AKT2 variants and their possible effects on insulin signaling. Highlights selected changes predicted to affect protein structure or function. Functional experiments and larger case-control studies are needed to establish relevance to diabetes.

In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles.

Mohammad Zubair; Fohad Mabood Husain; Marai Al-Amri; Imran Hasan; Iftekhar Hassan; Thamer Albalawi; Farha Fatima; Altaf Khan; Mohammed Arshad; Pravej Alam; Naved Ahmad; Roba Alatawy; Shamina Begum; Rashid Mir; Hisham Alshadfan; Abid Ali Ansari; Abeer Bader Abdi Al-Faqir Al-Anazi

Frontiers in cellular and infection microbiology · 2023 · 13: 1322778

Tests plant-stabilized tin oxide nanoparticles against resistant Candida albicans isolates from diabetic foot infections in vitro. Reports inhibition of biofilms and virulence-related activity, with oxidative stress as a possible mechanism. Clinical efficacy and safety are not established by these laboratory experiments.

Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus: A narrative review of randomized control trials.

Dharmsheel Shrivastav; Pradeep Kumar Dabla; Jitender Sharma; Aroop Viswas; Rashid Mir

World journal of diabetes · 2023 · 14(6): 919-929

Narratively reviews randomized trials of antioxidant strategies in type 2 diabetes. Synthesizes reported glycemic and oxidative-stress effects across 17 included trials. Differences among interventions and studies require care when interpreting potential clinical benefit.

Long non-coding RNAs modulate tumor microenvironment to promote metastasis: novel avenue for therapeutic intervention.

Sana Khurshid Baba; Sadaf Khursheed Baba; Rashid Mir; Imadeldin Elfaki; Naseh Algehainy; Mohammad Fahad Ullah; Jameel Barnawi; Faisal H Altemani; Mohammad Alanazi; Syed Khalid Mustafa; Tariq Masoodi; Ammira S Alshabeeb Akil; Ajaz A Bhat; Muzafar A Macha

Frontiers in cell and developmental biology · 2023 · 11: 1164301

Reviews how long non-coding RNAs shape the tumor microenvironment and metastatic behavior. Discusses metabolic reprogramming, resistance to anoikis and premetastatic niche formation. Evaluates potential biomarker and therapeutic applications as developing research avenues.

Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (Bcl-2/Bax) and Proinflammatory Cytokine (TNF-α/IL-8) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study.

Mamdoh S Moawadh; Rashid Mir; Faris J Tayeb; Orooba Asim; Mohammad Fahad Ullah

Current issues in molecular biology · 2023 · 45(5): 3933-3952

Studies apoptotic and inflammatory gene variants in myeloproliferative neoplasms using a case-control design. Reports differences involving BCL2, BAX, TNF-alpha and IL-8. Their suggested prognostic value requires further clinical validation.

Potential Impact of PI3K-AKT Signaling Pathway Genes, KLF-14, MDM4, miRNAs 27a, miRNA-196a Genetic Alterations in the Predisposition and Progression of Breast Cancer Patients.

Othman R Alzahrani; Rashid Mir; Hanan E Alatwi; Yousef M Hawsawi; Amnah A Alharbi; Abdulrahman H Alessa; Elham Saleh Albalawi; Imadeldin Elfaki; Yousef Alalawi; Laila Moharam; Sabah H El-Ghaiesh

Cancers · 2023 · 15(4): 1281

Examines PI3K-AKT-related variants and selected regulatory genes or microRNAs in breast cancer. Uses genotyping and whole-exome analysis to identify candidate associations with susceptibility and stage. Larger cohorts are needed to validate these findings.

Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival.

Sameer Ahmad Guru; Mamta Pervin Sumi; Rashid Mir; Mirza Masroor Ali Beg; Bidhan Chandra Koner; Alpana Saxena

BMC cancer · 2022 · 22(1): 405

Examines promoter hydroxymethylation of cell-cycle and apoptosis-related genes in chronic myeloid leukemia. Reports associations with advanced disease, imatinib response and survival. The linked correction should be consulted when interpreting this biomarker study.

Related correction

Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome.

Rashid Mir; Faris J Tayeb; Jameel Barnawi; Mohammed M Jalal; Nizar H Saeedi; Abdullah Hamadi; Malik A Altayar; Sanad E Alshammari; Nabil Mtiraoui; Mohammed Eltigani Ali; Faisel M Abu Duhier; Mohammad Fahad Ullah

International journal of environmental research and public health · 2022 · 19(5): 3114

Examines ESR1 and miR-146a polymorphisms alongside biochemical measures in polycystic ovary syndrome. Reports variant-specific associations, particularly involving miR-146a. Findings should be replicated before use for individual risk assessment.

Clinical Correlations of Lipid Profiles with the Age and Gender in the Coronary Artery Disease Patients: A Study of 3878 CAD Patients from India.

Rashid Mir; Imadeldin Elfaki; Ehab A M Frah; Khalid J Alzahrani; Mohammad Muzaffar Mir; Shaheena Banu

Endocrine, metabolic & immune disorders drug targets · 2022 · 22(4): 440-452

Analyzes age, sex and lipid profiles in 3878 Indian patients with coronary artery disease. Reports different lipid patterns across demographic groups and disease in some patients with normal lipids. These patient-cohort observations do not establish population-wide causal risk.

Clinical Implications of Glyoxalase1 Gene Polymorphism and Elevated Levels of the Reactive Metabolite Methylglyoxal in the Susceptibility of Type 2 Diabetes Mellitus in the Patients from Asir and Tabuk Regions of Saudi Arabia.

Muhanad Alhujaily; Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Javed Iqbal Wani; Zia Ul Sabah; Imadeldin Elfaki; Tarig Mohammad Saad Alnour; Mohammed Jeelani; Mosleh Mohammad Abomughaid; Samir Abdulkarim Alharbi

Journal of personalized medicine · 2022 · 12(4): 639

Examines GLO1 polymorphism and circulating methylglyoxal in type 2 diabetes. Reports genotype-dependent susceptibility associations and higher methylglyoxal in patients. Larger population and functional studies are needed to confirm the proposed mechanism.

Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic Predisposition to PCOS.

Rashid Mir; Nizar H Saeedi; Mohammed M Jalal; Malik A Altayar; Jameel Barnawi; Abdullah Hamadi; Faris J Tayeb; Sanad E Alshammari; Nabil Mtiraoui; Mohammed Eltigani M Ali; Faisel M Abuduhier; Mohammad Fahad Ullah

Journal of personalized medicine · 2022 · 12(4): 586

Examines KLF14 and selected microRNA variants in polycystic ovary syndrome. Reports associations for several genotypes, with differing results across the microRNAs assessed. The findings remain candidate susceptibility markers requiring independent confirmation.

Clinical Utility of Amplification Refractory Mutation System-Based PCR and Mutation-Specific PCR for Precise and Rapid Genotyping of Angiotensin-Converting Enzyme 1 (ACE1-rs4646996 D>I) and Angiotensin-Converting Enzyme 2 (ACE2-rs4240157T>C) Gene Variations in Coronary Artery Disease and Their Strong Association with Its Disease Susceptibility and Progression.

Aadil Yousif; Rashid Mir; Jamsheed Javid; Jameel Barnawi; Mohammed M Jalal; Malik A Altayar; Salem Owaid Albalawi; Faisel M Abuduhier

Diagnostics (Basel, Switzerland) · 2022 · 12(6): 1321

Evaluates PCR methods for genotyping selected angiotensin-converting enzyme variants in coronary disease. Reports associations with susceptibility and related cardiometabolic features. Larger longitudinal studies are needed to validate the proposed genetic markers.

Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study.

Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Javed Iqbal Wani; Zia Ul Sabah; Mohammed Jeelani; Vijaya Marakala; Shahzada Khalid Sohail; Mohamed O'haj; Muffarah Hamid Alharthi; Mohannad Mohammad S Alamri

Journal of personalized medicine · 2022 · 12(5): 735

Compares adipokine concentrations in type 2 diabetes across obesity categories and controls. Reports altered adiponectin, leptin, visfatin and chemerin profiles. Larger prospective studies are needed to clarify their roles in progression and complications.

Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.

Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Badr Abdulmohsin Alsayed; Imadeldin Elfaki; Ali Al Bshabshe; Rabia Farooq; Muhanad Alhujaily; Muffarah Hamid Alharthi; Mohannad Mohammad S Alamri; Abdullah M Al-Shahrani

Experimental and therapeutic medicine · 2022 · 23(6): 418

Examines angiotensin-converting enzyme-related and miR-196a2 variants in COVID-19 severity and mortality. Reports genotype and allele associations in the studied cohort. Replication in larger samples and different populations is necessary.

Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.

Rashid Mir; Imadeldin Elfaki; Jamsheed Javid; Jameel Barnawi; Malik A Altayar; Salem Owaid Albalawi; Mohammed M Jalal; Faris J Tayeb; Aadil Yousif; Mohammad Fahad Ullah; Faisel M AbuDuhier

Life (Basel, Switzerland) · 2022 · 12(11): 1905

Examines eNOS3, KLF14, MTHFR and miR-27a variants in coronary artery disease. Reports genotype associations with susceptibility in the studied population. Larger population studies are needed to establish reproducibility and clinical prediction value.

IL-2 and IL-1β Patient Immune Responses Are Critical Factors in SARS-CoV-2 Infection Outcomes.

Shereen Fawzy; Mesaik M Ahmed; Badr A Alsayed; Rashid Mir; Dnyanesh Amle

Journal of personalized medicine · 2022 · 12(10): 1729

Compares inflammatory cytokines and clinical measures in COVID-19 survivors, non-survivors and controls. Reports outcome-related differences involving IL-1beta, IL-2 and IL-8. The observational findings generate hypotheses about immune responses rather than prove a treatment strategy.

Ionized Blood Magnesium in Sick Children: An Overlooked Electrolyte.

Pradeep Kumar Dabla; Shikha Sharma; Aashima Dabas; Vernika Tyagi; Shipra Agrawal; Urmila Jhamb; Dennis Begos; Kamal Upreti; Rashid Mir

Journal of tropical pediatrics · 2022 · 68(2): fmac022

Measures ionized magnesium and related electrolytes in critically ill children. Reports both low and high magnesium levels and links between hypomagnesemia and other electrolyte abnormalities. The observational findings support attention to electrolyte assessment rather than establish treatment effects.

Molecular determination of progesterone receptor's PROGINS allele (Alu insertion) and its association with the predisposition and susceptibility to polycystic ovary syndrome (PCOS).

Rashid Mir; Malik A Altayar; Abdullah Hamadi; Faris J Tayeb; Nizar H Saeedi; Mohammed M Jalal; Jameel Barnawi; Sanad E Alshammari; Nabil Mtiraoui; Mohammed Eltigani M Ali; Faisel M Abuduhier; Mohammad Fahad Ullah

Mammalian genome : official journal of the International Mammalian Genome Society · 2022 · 33(3): 508-516

Examines the progesterone-receptor PROGINS insertion in polycystic ovary syndrome. Reports increased variant frequency and associations with lower progesterone in patients. Further work is needed to establish its contribution to susceptibility and progesterone resistance.

Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease.

Abdullah Hamadi; Rashid Mir; Ali Mahzari; Abdulrahim Hakami; Reema Almotairi; Gasim Dobie; Fawaz Hamdi; Mohammed Hassan Nahari; Razan Alhefzi; Mohammed Alasseiri; Nora Y Hakami; Hadeel Al Sadoun; Osama M Al-Amer; Jameel Barnawi; Hassan A Madkhali

Current issues in molecular biology · 2022 · 44(6): 2569-2582

Uses ARMS-PCR to genotype VEGF and miR-423 variants in sickle cell disease. Examines their relationships with fetal and sickle hemoglobin levels. The reported associations require confirmation in larger studies.

Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia.

Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Javed Iqbal Wani; Imadeldin Elfaki; Zia Ul Sabah; Muhanad Alhujaily; Mohammed Jeelani; Vijaya Marakala; Muffarah Hamid Alharthi; Abdullah M Al-Shahrani

Molecular medicine reports · 2022 · 25(5): 162

Examines GCK, MIR196A2 and MIR423 variants in type 2 diabetes in Asir and Tabuk. Reports candidate genotype associations with susceptibility. Larger longitudinal and multi-population studies are needed for validation.

Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification.

Mohammad Hashim; Hussain Arif; Baby Tabassum; Amin Arif; Ahmed A Rehman; Shahnawaz Rehman; Rehnuma Khanam; Bushra Khan; Arif Hussain; Jameel Barnawi; Faris J Tayeb; Naseh Algehainy; Faisal H Altemani; Rashid Mir; Fahad M Almutairi; Mohammad Fahad Ullah; Imadeldin Elfaki; Mohammad Rehan Ajmal

Metabolites · 2022 · 12(11): 1059

Tests Catharanthus roseus extract in a rat model of cadmium toxicity. Reports changes consistent with reduced oxidative stress and tissue DNA damage. These preclinical observations do not establish benefit or safety in humans.

Role of the Tumor Microenvironment and the Influence of Epigenetics on the Tumor Microenvironment in Oral Carcinogenesis: Potential Implications.

Sagar Dholariya; Ragini D Singh; Madhuri Radadiya; Deepak Parchwani; Gaurav Sharma; Rashid Mir

Critical reviews in oncogenesis · 2022 · 27(4): 47-64

Reviews tumor microenvironment components and epigenetic changes in oral carcinogenesis. Discusses their combined effects on tumor development and progression. Identifies possible therapeutic targets for future investigation.

Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review.

Badr A Alsayed; Rashid Mir

Cureus · 2022 · 14(3): e23636

Describes a severe COVID-19 case and investigates selected genetic variants. Discusses possible susceptibility factors alongside a literature review. The single-patient observation cannot establish independent genetic risk or causation.

Significant Association of Antiepileptic Drug Polytherapy with Decreased FT4 Levels in Epileptic Patients.

P K Dabla; S Sharma; R Mir; V Puri

Indian journal of clinical biochemistry : IJCB · 2022 · 37(1): 107-112

Examines thyroid hormone levels in epilepsy patients receiving antiepileptic monotherapy or polytherapy. Reports lower free T4 associated with polytherapy and higher carbamazepine levels. The observational findings support further study of medication-related thyroid changes.

Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.

Sheema Hashem; Tayyiba Akbar Ali; Sabah Akhtar; Sabah Nisar; Geetanjali Sageena; Shahid Ali; Sharefa Al-Mannai; Lubna Therachiyil; Rashid Mir; Imadeldin Elfaki; Mohammad Muzaffar Mir; Farrukh Jamal; Tariq Masoodi; Shahab Uddin; Mayank Singh; Mohammad Haris; Muzafar Macha; Ajaz A Bhat

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022 · 150: 113054

Reviews natural products that act on signaling pathways implicated in cancer. Discusses multi-target effects and their potential contribution to anticancer drug discovery. Promising molecular activity does not itself establish clinical effectiveness.

The Role of Inflammatory and Cytokine Biomarkers in the Pathogenesis of Frailty Syndrome.

Rashid Mir; Chandan K Jha; Naina Khullar; Mohsin Maqbool; Pradeep K Dabla; Suruchi Mathur; Amal Moustafa; Uzma A Faridi; Abdullah Hamadi; Mohammad Muzaffar Mir; Faisel M Abu Duhier

Endocrine, metabolic & immune disorders drug targets · 2022 · 22(14): 1357-1366

Reviews inflammation, cytokines and vitamin D in the pathogenesis of frailty. Discusses biological aging and possible markers of vulnerability. The review identifies mechanisms and research questions rather than a definitive diagnostic panel.

Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.

Rashid Mir; Imadeldin Elfaki; Chandan K Jha; Jamsheed Javid; Abdullatif T Babakr; Shaheena Banu; Mohammad M Mir; Dheeraj Jamwal; Naina Khullar; Khalid J Alzahrani; Sukh M S Chahal

Cardiovascular & hematological disorders drug targets · 2021 · 21(4): 266-277

Examines TNF-alpha promoter and CYP1B1 variants in coronary artery disease. Reports a CYP1B1 association while the assessed TNF-alpha variant was not associated with susceptibility. Larger studies are needed before clinical interpretation.

Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D.

Imadeldin Elfaki; Rashid Mir; Faisel M Abu Duhier; Maeidh A Alotaibi; Adel Ibrahim Alalawy; Jameel Barnawi; Abdullatif Taha Babakr; Mohammad Muzaffar Mir; Faris Altayeb; Hyder Mirghani; Ehab A M Frah

Current issues in molecular biology · 2021 · 43(3): 1859-1875

Examines miR128, ACE and VEGF variants in type 2 diabetes. Reports differing susceptibility associations across the loci assessed. Population replication and protein-function studies are needed before application in risk screening.

Epigenetic Silencing of DAPK1and p16 INK4a Genes by CpG Island Hypermethylation in Epithelial Ovarian Cancer Patients.

Mariyam Zuberi; Sagar Dholariya; Imran Khan; Rashid Mir; Sameer Guru; Musadiq Bhat; Mamta Sumi; Alpana Saxena

Indian journal of clinical biochemistry : IJCB · 2021 · 36(2): 200-207

Examines DAPK1 and p16INK4a promoter methylation in epithelial ovarian cancer. Reports higher methylation frequencies in cases than controls. The proposed use in ancillary diagnosis needs further validation beyond this study.

Metastatic Breast Cancer, Organotropism and Therapeutics: A Review.

Ajaz Ahmad Waza; Najeebul Tarfeen; Sabhiya Majid; Yasmeena Hassan; Rashid Mir; Mohd Younis Rather; Naseer Ue Din Shah

Current cancer drug targets · 2021 · 21(10): 813-828

Reviews how breast cancer spreads to particular organs. Discusses molecular processes underlying metastasis and organ preference. Summarizes therapeutic advances and continuing challenges in treating metastatic disease.

Molecular Determination of mirRNA-126 rs4636297, Phosphoinositide-3-Kinase Regulatory Subunit 1-Gene Variability rs7713645, rs706713 (Tyr73Tyr), rs3730089 (Met326Ile) and Their Association with Susceptibility to T2D.

Rashid Mir; Imadeldin Elfaki; Faisel M Abu Duhier; Maeidh A Alotaibi; Adel Ibrahim AlAlawy; Jameel Barnawi; Abdullatif Taha Babakr; Mohammad Muzaffar Mir; Hyder Mirghani; Abdullah Hamadi; Pradeep Kumar Dabla

Journal of personalized medicine · 2021 · 11(9): 861

Examines miR126 and PIK3R1 variants in type 2 diabetes. Reports associations involving selected microRNA and signaling-gene polymorphisms. Larger cohorts and enzyme or protein-function studies are needed to test biological significance.

Molecular Evaluation of Exon 8 Cystathionine rs5742905T T>C Gene Polymorphism and Determination of its Frequency, Distribution Pattern, and Association with Susceptibility to Coronary Artery Disease in the North Indian Population.

Mamta P Sumi; Sameer A Guru; Rashid Mir; Samantak Sahu; Musadiq A Bhat; M P Girish; Alpana Saxena

Cardiovascular & hematological disorders drug targets · 2021 · 21(2): 115-122

Examines a CBS exon-8 variant in North Indian coronary artery disease patients and controls. Reports associations with disease susceptibility but no significant relationship with severity in the analyzed comparison. The findings require replication before clinical risk prediction.

Molecular Evaluation of HIF-1α Gene Variation and Determination of Its Frequency and Association with Breast Cancer Susceptibility in Saudi Arabia.

Rashid Mir; Faisel M Abu-Duhier; Ibrahim A Albalawi

Endocrine, metabolic & immune disorders drug targets · 2021 · 21(3): 544-553

Examines HIF1alpha variation in Saudi breast cancer patients and controls. Reports associations with susceptibility, stage and distant metastasis. Larger datasets and improved models are needed to confirm the findings.

Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis.

Rashid Mir; Imadeldin Elfaki; Naina Khullar; Ajaz Ahmad Waza; Chandan Jha; Mohammad Muzaffar Mir; Shamsu Nisa; Babar Mohammad; Tahir Ahmad Mir; Mohsin Maqbool; Jameel Barnawi; Salem Owaid Albalawi; Faisel M Abu-Duhier

Journal of cardiovascular development and disease · 2021 · 8(2): 22

Reviews selected circulating microRNAs in coronary artery disease, myocardial infarction and atherosclerosis. Discusses their stability, detectability and proposed diagnostic or prognostic value. Considers combined marker panels while highlighting the need for validation.

Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease Mortality.

Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Badr Abdulmohsin Alsayed; Javed Iqbal Wani; Muffarah Hamid Alharthi; Abdullah M Al-Shahrani

Journal of personalized medicine · 2021 · 11(11): 1098

Investigates angiotensin-converting enzyme-related polymorphisms in COVID-19 and cardiometabolic disease. Reports associations with severity, comorbidity and mortality. These cohort findings require independent validation for risk stratification.

Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study.

Imadeldin Elfaki; Rashid Mir; Faisel Mohammed Abu-Duhier; Chandan Kumar Jha; Adel Ibrahim Ahmad Al-Alawy; Abdullatif Taha Babakr; Salem Abd El-Hadi Habib

Current drug metabolism · 2020 · 21(14): 1152-1160

Compares CYP2C9*3 and CYP2C19*3 variants in a type 2 diabetes case-control study. Reports a possible CYP2C19*3 association and no association for CYP2C9*3. Larger studies across populations are needed to validate this distinction.

Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5.

Sameer Ahamd Guru; Mamta P Sumi; Rashid Mir; Ajaz Ahmad Waza; Musadiq Ahmad Bhat; Mariyam Zuberi; Promod Lali; Alpana Saxena

Human cell · 2020 · 33(4): 1099-1111

Examines PD-L1 expression and STAT signaling in JAK2 V617F myeloproliferative neoplasms. Reports relationships between mutant allele burden, PD-L1 and STAT3 or STAT5 activation. A linked correction resolves an author-name error and should accompany the citation.

Related correction

Genetic Effects of Vascular Endothelial Growth Factor A (VEGF-A) and Its Association with Disease Progression in Breast Cancer Population of Saudi Arabia.

Ibrahim Altedlawi Albalawi; Rashid Mir; F M Abu Duhier

Asian Pacific journal of cancer prevention : APJCP · 2020 · 21(1): 139-145

Examines VEGF-A variation in Saudi breast cancer patients. Reports associations involving the studied variant and disease susceptibility or distant metastasis. Larger studies are needed before it can be treated as a validated genetic marker.

Heterozygosity in LDLR rs2228671 and rs72658855 Gene is Associated with Increased Risk of Developing Coronary Artery Disease in India -A Case-Control Study.

Chandan K Jha; Rashid Mir; Shaheena Banu; Imadeldin Elfaki; Sukh M S Chahal

Endocrine, metabolic & immune disorders drug targets · 2020 · 20(3): 388-399

Examines two LDLR variants in an Indian coronary disease case-control study. Reports susceptibility associations involving heterozygous genotypes and one allele. Independent larger studies are needed to validate the results.

Molecular Evaluation of MicroRNA-146 Gene Variability (rs2910164 C> G) and its Association with Increased Susceptibility to Coronary Artery Disease.

Rashid Mir; Imadeldin Elfaki; Chandan Jha; Jamsheed Javid; Suriya Rehman; Shaheena Banu; Mohammad Muzaffar Mir; Abdullatif Taha Babakr; Sukh Mohinder Singh Chahal

MicroRNA (Shariqah, United Arab Emirates) · 2020 · 9(5): 363-372

Genotypes miR-146a rs2910164 in coronary artery disease cases and controls. Reports associations of selected genotypes and alleles with susceptibility. Larger datasets are needed to confirm the genetic relationship.

Molecular Evaluation of PROGINS Mutation in Progesterone Receptor Gene and Determination of its Frequency, Distribution Pattern and Association with Breast Cancer Susceptibility in Saudi Arabia.

Ibrahim A Albalawi; Rashid Mir; Fasel M Abu-Duhier

Endocrine, metabolic & immune disorders drug targets · 2020 · 20(5): 760-770

Evaluates a mutation-specific PCR assay for progesterone-receptor PROGINS variation in Saudi breast cancer. Reports associations with susceptibility, stage and metastasis. The assay and proposed clinical relevance require independent larger-scale validation.

Natural Killer Cells Expanded and Preactivated Exhibit Enhanced Antitumor Activity against Different Tumor Cells in Vitro.

Biplob Kumar Biswas; Sameer Ahmad Guru; Mamta Pervin Sumi; Elvia Jamatia; Rohit Kumar Gupta; Pramod Lali; Bidhan Chandra Konar; Alpana Saxena; Rashid Mir

Asian Pacific journal of cancer prevention : APJCP · 2020 · 21(6): 1595-1605

Expands and preactivates natural killer cells and tests their activity against tumor cells in vitro. Reports enhanced antitumor effects, apoptosis and reduced survivin expression. These laboratory results require further investigation before clinical application.

Phosphatidylinositol 3-kinase Glu545Lys and His1047Tyr Mutations are not Associated with T2D.

Imadeldin Elfaki; Rashid Mir; Faisel M Abu-Duhier; Roaid Khan; Mohammed Sakran

Current diabetes reviews · 2020 · 16(8): 881-888

Tests selected PI3K mutations in a type 2 diabetes case-control study. Finds no significant association for the assessed Glu545Lys and His1047Tyr changes. Larger studies in other populations are recommended to evaluate these negative findings.

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.

Ajaz A Bhat; Salma N Younes; Syed Shadab Raza; Lubna Zarif; Sabah Nisar; Ikhlak Ahmed; Rashid Mir; Sachin Kumar; Surender K Sharawat; Sheema Hashem; Imadeldin Elfaki; Michal Kulinski; Shilpa Kuttikrishnan; Kirti S Prabhu; Abdul Q Khan; Santosh K Yadav; Wael El-Rifai; Mohammad A Zargar; Hatem Zayed; Mohammad Haris; Shahab Uddin

Molecular cancer · 2020 · 19(1): 57

Reviews non-coding RNA networks in leukemia development, progression and treatment resistance. Discusses expression patterns and functions of different RNA classes. Evaluates potential diagnostic, prognostic and therapeutic uses; a linked correction should accompany the article.

Related correction

The Promising Signatures of Circulating microRNA-145 in Epithelial Ovarian Cancer Patients.

Mariyam Zuberi; Rashid Mir; Imran Khan; Jamsheed Javid; Sameer Ahmad Guru; Musadiq Bhat; Mamta Pervin Sumi; Imtiyaz Ahmad; Mirza Masroor; Prasant Yadav; Sreenivas Vishnubhatla; Alpana Saxena

MicroRNA (Shariqah, United Arab Emirates) · 2020 · 9(1): 49-57

Measures circulating miR145 in 70 epithelial ovarian cancer patients and 70 controls. Reports lower expression and associations with clinical features, evaluating diagnostic and prognostic performance. Independent validation is needed before clinical biomarker use.

Clinical Importance of Estrogen Receptor 1 (ESR1) Gene Polymorphisms and Their Expression Patterns in Coronary Artery Disease Patients: A Study from India.

Mamta P Sumi; Sameer Ahmad Guru; Rashid Mir; Mirza Masroor; Musadiq A Bhat; M P Girish; Alpana Saxena

Indian journal of clinical biochemistry : IJCB · 2019 · 34(2): 133-142

Examines ESR1 variants and receptor-expression patterns in North Indian coronary artery disease. Reports associations of selected genotypes with susceptibility and lower receptor mRNA expression. These results identify a potential biological link requiring independent validation.

Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study.

Chandan K Jha; Rashid Mir; Imadeldin Elfaki; Jamsheed Javid; Abdullatif Taha Babakr; Shaheena Banu; S M S Chahal

Journal of personalized medicine · 2019 · 9(2): 30

Examines two omentin-1 variants in Indian coronary artery disease patients and controls. Reports an association involving rs2274907 and selected metabolic or clinical features. Functional research and larger independent samples are needed for confirmation.

Incidence of MicroR-4513C/T Gene Variability in Coronary Artery Disease - A Case-Control Study.

Rashid Mir; Chandan K Jha; Imadeldin Elfaki; Jamsheed Javid; Suriya Rehman; Naina Khullar; Shaheena Banu; S M S Chahal

Endocrine, metabolic & immune disorders drug targets · 2019 · 19(8): 1216-1223

Genotypes miR4513 rs2168518 in 100 coronary disease cases and 100 controls. Reports genotype and allele associations with susceptibility. Larger studies are needed to confirm the proposed risk marker.

LDLR Gene Polymorphisms (rs5925 and rs1529729) Are Associated with Susceptibility to Coronary Artery Disease in a South Indian Population.

Chandan K Jha; Rashid Mir; Imadeldin Elfaki; Shaheena Banu; S M S Chahal

Medical sciences (Basel, Switzerland) · 2019 · 7(7): 80

Examines LDLR rs5925 and rs1529729 in a South Indian population. Reports selected genotypes associated with lower coronary disease susceptibility. These population-specific findings require replication before clinical genetic screening.

MicroRNA-224 (rs188519172 A>G) Gene Variability is Associated with a Decreased Susceptibility to Coronary Artery Disease: A Case-Control Study.

Rashid Mir; Chandan K Jha; Imadeldin Elfaki; Suriya Rehman; Jamsheed Javid; Naina Khullar; Shaheena Banu; Sukh Mohinder Singh Chahal

MicroRNA (Shariqah, United Arab Emirates) · 2019 · 8(3): 198-205

Examines miR224 variation in a coronary artery disease case-control study. Reports a selected genotype associated with reduced susceptibility. Further population and functional studies are needed to clarify the relationship.

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease.

Imadeldin Elfaki; Rashid Mir; Mohammad Muzaffar Mir; Faisel M AbuDuhier; Abdullatif Taha Babakr; Jameel Barnawi

Journal of personalized medicine · 2019 · 9(4): 51

Reviews microRNA gene polymorphisms in diabetes and atherosclerotic cardiovascular disease. Discusses population associations and possible effects on gene regulation. Identifies mechanisms and questions for further susceptibility research.

Potential Impact of MicroRNA-423 Gene Variability in Coronary Artery Disease.

Chandan K Jha; Rashid Mir; Imadeldin Elfaki; Naina Khullar; Suriya Rehman; Jamsheed Javid; Shaheena Banu; Sukh Mohinder Singh Chahal

Endocrine, metabolic & immune disorders drug targets · 2019 · 19(1): 67-74

Examines miR423 genetic variation in coronary disease patients and matched controls. Reports susceptibility associations involving selected genotype and allele comparisons. Larger independent studies are needed to confirm these candidate genetic links.

A Germline Mutation in the BRCA1 3’UTR Variant Predicts Susceptibility to Breast Cancer in a Saudi Arabian Population.

Rashid Mir; Jamsheed Javid; Ibrahim Abdullah Al Balawi; Khaled R. Alkharsah; Maha Abdel Hadi; Mostafa Abdel Rahman; Ebtesam Hamoud; Yousef Al Alawi; Attiya Bin Mohammad Al Zahrani; F M Abu-Duhier

Asian Pacific journal of cancer prevention : APJCP · 2018 · 19(3): 859-866

Examines a BRCA1 3-prime untranslated-region variant in Saudi breast cancer. Reports associations with susceptibility and selected disease features. This common-variant association should not be equated with the clinical significance of established pathogenic BRCA1 mutations.

Association of GABAA Receptor Gene with Epilepsy Syndromes.

Musadiq Ahmad Bhat; Sameer Ahmad Guru; Rashid Mir; Ajaz Ahmad Waza; Mariyam Zuberi; Mamta Pervin Sumi; Shaam Bodeliwala; Vinod Puri; Alpana Saxena

Journal of molecular neuroscience : MN · 2018 · 65(2): 141-153

Examines GABAA receptor variants in juvenile myoclonic epilepsy and Lennox-Gastaut syndrome. Reports possible associations with syndrome susceptibility, seizure characteristics and drug response. These genetic relationships require confirmation before therapeutic decisions.

Involvement of microRNA-423 Gene Variability in Breast Cancer Progression in Saudi Arabia.

R Mir; I A Al Balawi; F M Abu Duhier

Asian Pacific journal of cancer prevention : APJCP · 2018 · 19(9): 2581-2589

Examines miR423 gene variation in Saudi breast cancer patients. Reports associations involving selected genotypes, susceptibility, metastasis and advanced disease. Larger studies are needed to confirm these population-specific findings.

LDLR rs688 TT Genotype and T Allele Are Associated with Increased Susceptibility to Coronary Artery Disease-A Case-Control Study.

Chandan K Jha; Rashid Mir; Naina Khullar; Shaheena Banu; S M S Chahal

Journal of cardiovascular development and disease · 2018 · 5(2): 31

Examines LDLR rs688 in a coronary artery disease case-control study. Reports an association of the TT genotype and T allele with susceptibility. The result is a candidate population association requiring independent validation.

Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease.

Rashid Mir; Musadiq Bhat; Jamsheed Javid; Chandan Jha; Alpana Saxena; Shaheen Banu

Journal of cardiovascular development and disease · 2018 · 5(3): 38

Examines COMT rs4680 in Indian coronary artery disease patients and controls. Reports an association between selected variants and increased susceptibility. Larger samples are needed to establish reproducibility and clinical relevance.

A deletion polymorphism in the RIZ gene is associated with increased progression of imatinib treated chronic myeloid leukemia patients.

Rashid Mir; Imtiyaz Ah Najar; Sameer Guru; Jamsheed Javaid; Prasant Yadav; Mirza Masroor; Mariyam Zuberi; Shazia Farooq; Musadiq Bhat; Naresh Gupta; Prakash Chander Ray; Alpana Saxena

Leukemia & lymphoma · 2017 · 58(7): 1694-1701

Examines a RIZ deletion polymorphism in imatinib-treated chronic myeloid leukemia. Reports genotype differences and associations with progression-related features. The proposed prognostic role requires replication and further biological investigation.

GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.

Faisel Abu-Duhier; Rashid Mir

Hematology (Amsterdam, Netherlands) · 2017 · 22(3): 172-177

Examines GSTM1 and GSTT1 genotypes in sickle cell disease cases and controls from Tabuk. Reports an association involving GSTT1-null status and differences in hemoglobin measures. The study assesses a possible modifier; it does not identify the primary cause of sickle cell disease.

Clinical implications of cytosine deletion of exon 5 of P53 gene in non small cell lung cancer patients.

Rashid Mir; Mirza Masroor; Jamsheed Javid; Imtiyaz Ahamad; Shazia Farooq; Prasant Yadav; Mariyam Zuberi; Maqbool Lone; P C Ray; Alpana Saxena

South Asian journal of cancer · 2016 · 5(1): 33-6

Genotypes a TP53 exon-5 cytosine deletion in non-small cell lung cancer patients. Reports associations with smoking, metastasis, stage and progression-related observations. The findings support additional validation of its potential prognostic relevance.

Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.

P Yadav; M Masroor; K Tanwer; R Mir; J Javid; I Ahmad; M Zuberi; R C M Kaza; S K Jain; N Khurana; P C Ray; A Saxena

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016 · 18(7): 728-34

Examines TP53 and MDM2 polymorphisms in North Indian breast cancer patients. Reports a TP53 susceptibility association and relationships between selected variants and tumor features. These candidate associations require replication and do not establish a clinical genetic test.

Involvement of CASP3 promoter polymorphism (-1337 C > G) in the development and progression of non-small cell lung cancer.

Jamsheed Javid; Rashid Mir; Alpana Saxena

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016 · 37(7): 9255-62

Examines a CASP3 promoter variant and gene expression in non-small cell lung cancer. Reports lower expression and poorer survival associated with the GG genotype. These observational associations require independent confirmation and mechanistic study.

Potential impact of (rs 4645878) BAX promoter -248G>A and (rs 1042522) TP53 72Arg>pro polymorphisms on epithelial ovarian cancer patients.

S Dholariya; R Mir; M Zuberi; P Yadav; G Gandhi; N Khurana; A Saxena; P C Ray

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016 · 18(1): 73-81

Examines BAX and TP53 polymorphisms in epithelial ovarian cancer patients and controls. Reports genotype and combined-variant associations with susceptibility and disease features. Independent larger studies are needed to validate these possible genetic modifiers.

Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.

Mirza Masroor; Jamsheed Javid; Rashid Mir; Prasant Y; Imtiyaz A; Mariyam Z; Anant Mohan; P C Ray; Alpana Saxena

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016 · 37(1): 857-63

Measures circulating ERBB3 and ERBB4 mRNA in lung adenocarcinoma. Reports associations between higher expression, metastatic features and shorter survival. Prospective validation is needed before using these measures for clinical monitoring.

Utility of Serum miR-125b as a Diagnostic and Prognostic Indicator and Its Alliance with a Panel of Tumor Suppressor Genes in Epithelial Ovarian Cancer.

Mariyam Zuberi; Imran Khan; Rashid Mir; Gauri Gandhi; Prakash Chandra Ray; Alpana Saxena

PloS one · 2016 · 11(4): e0153902

Measures serum miR125b and evaluates tumor-suppressor-gene methylation in epithelial ovarian cancer. Reports altered expression and associations with stage, metastasis and clinical outcome. Independent validation is needed to resolve mechanism and clinical biomarker utility.

Association of 18bp insertion/deletion polymorphism, at -2549 position of VEGF gene, with diabetic nephropathy in type 2 diabetes mellitus patients of North Indian population.

Dnyanesh Amle; Rashid Mir; Alka Khaneja; Sarita Agarwal; Ravinder Ahlawat; Prakash C Ray; Alpana Saxena

Journal of diabetes and metabolic disorders · 2015 · 14: 19

Examines a VEGF insertion/deletion variant across diabetic nephropathy, uncomplicated diabetes and control groups. Reports higher susceptibility associated with the deletion genotype or allele in a North Indian population. Larger studies are needed to confirm its value as a risk marker.

Expression of serum miR-200a, miR-200b, and miR-200c as candidate biomarkers in epithelial ovarian cancer and their association with clinicopathological features.

M Zuberi; R Mir; J Das; I Ahmad; J Javid; P Yadav; M Masroor; S Ahmad; P C Ray; A Saxena

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2015 · 17(10): 779-87

Measures circulating miR200a, miR200b and miR200c in epithelial ovarian cancer. Reports increased expression and associations with progression and selected clinical features. The linked erratum should accompany the citation and independent biomarker validation is needed.

Related correction

Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.

Rashid Mir; Imtiyaz Ah; Jamsheed Javid; Mariyam Zuberi; Sameer Guru; Masroor Mirza; Shazia Farooq; Prasant Yadav; Prakash C Ray; Naresh Gupta; Alpana Saxena

World journal of oncology · 2015 · 6(2): 321-328

Examines HRAS T81C in imatinib-treated chronic myeloid leukemia patients. Reports associations with disease phases, treatment response and selected clinical features. These results identify a candidate prognostic relationship requiring independent validation.